Toward the stereochemical assignment and synthesis of hemicalide: DP4f GIAO-NMR analysis and synthesis of a reassigned C16-C28 subunit.
نویسندگان
چکیده
Using the DP4f GIAO-NMR method, the stereochemistry of hemicalide was computationally analysed, resulting in a reassignment at C18 as supported by improved NMR shift correlations with a model C13-C25 fragment 23. An advanced C16-C28 subunit 6 of this potent anticancer agent was then synthesised with the revised 18,19-syn relationship.
منابع مشابه
A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide.
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ورودعنوان ژورنال:
- Chemical communications
دوره 52 25 شماره
صفحات -
تاریخ انتشار 2016